Multiple postdoctoral fellow positions are available in Dr. Min Dong’s lab at Boston Children’s Hospital and Harvard Medical School. Our laboratory has a broad interest in microbial toxins and host-microbe interactions. We are also interested in membrane trafficking and cytoskeleton remodeling in neurons. Along these lines of basic research, we are keen in developing microbial toxin-inspired scientific tools and novel therapeutics. We have a multi-disciplinary team crossing microbiology, protein engineering, cell biology, and neuroscience fields. Recent achievements include identification of receptors for C. difficile toxin via genome-wide CRISPR-Cas9 screen (Nature, 2016, 538:350), identification of a novel botulinum neurotoxin (Nature Communications, 2017, 8:14130), and improving the therapeutic property of botulinum neurotoxins through protein engineering (Nature Communications, 2017, 8:53). Please see lab website for details: http://donglab.hms.harvard.edu.
Potential projects include:
(1) Mechanism of bacterial toxins and effectors: we are studying botulinum neurotoxins, tetanus neurotoxin, Shiga toxin, Clostridium difficile toxins, and many bacterial effectors using latest experimental approaches.
(2) Host-microbe interactions: enteric pathogens (e.g., C. difficile infections) and microbiome; urinary tract infections and urinary microbiome.
(3) Developing novel therapeutic toxins: apply modern protein engineering methods to develop novel therapeutic toxins for treating chronic pain and cancer. These positions will have many opportunities to work closely with our industry partners.
(4) Cell biology of neurons / electrophysiology: the candidate will apply imaging and electrophysiological approaches to characterize a few newly generated knock-out/knock-in mouse lines, focusing on (1) synaptic vesicle exocytosis/recycling; (2) cytoskeleton regulation by ROCO kinases; (3) endosomal sorting and trafficking in cells.
Interested candidates please forward your curriculum vitae and names of three references to Dr. Min Dong by email: email@example.com